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KMID : 1144820190250030267
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대한의생명과학회지
2019 Volume.25 No. 3 p.267 ~ p.274
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Dehydrocostus Lactone Suppresses the Expression of iNOS Induced by TLR Agonists
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Kim Su-Yeon
Heo Sung-Hye
Kim Seung-Han
Kwon Min-Ji
Park Sin-Aye
Youn Hyung-Sun
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Abstract
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Toll-like receptors (TLRs) are one of the families of pattern recognition receptors (PRR) to recognize pathogen-associated molecular patterns (PAMPs). PAMPs stimulate TLRs to initiate specific immunoactivity. The activation of TLRs signaling leads to the expression of pro-inflammatory gene products such as cytokines and inducible nitric oxide synthase (iNOS). To evaluate the therapeutic potential of dehydrocostus lactone (DHL), which is a natural sesquiterpene lactone derived from various medicinal plants, iNOS expression induced by LPS (TLR4 agonist), MALP-2 (TLR2 and TLR6 agonist), or Poly[I:C] (TLR3 agonist) were examined. DHL suppressed the iNOS expression induced by LPS, MALP-2, or Poly[I:C]. DHL also inhibited nitrite production induced by LPS, MALP-2, or Poly[I:C]. These results suggest that DHL can modulate TLRs signaling pathways resulting in anti-inflammatory effect.
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KEYWORD
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Dehydrocostus lactone, Inducible nitric oxide synthase, TLR, Inflammation, LPS
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